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KMID : 0363319970180010069
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Journal of Korean Oriental Internal Medicine
1997 Volume.18 No. 1 p.69 ~ p.85
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Study on the Anti-inflammatory, Analgesic and Anti-thrombotic Effects of Shintongchugeotang in the Experimental Animals
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Liu Ji-Yong
Lee Key-Sang
Moon Byung-Soon
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Abstract
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This study was designed to elucidate the anti-inflammatory, cardiovascular, anti-thrombotic and analgesic effects of Shintongchugeotang. The anti-inflammatory effect was measured by the method of carragenin induced edema, protein leakage test using CMC-pouch, and the analgesic effect was measured by the acetic acid method and hot plate method, and the effect of Shintongchugeotang on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit, and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity was observed for the measurement of the anti-coagurative effect of Shintongchugeotang.
The result was as follows :
1. After the administration of Shintongchugeotang extract, Carragenin induced edema and CMC-pouch protein leakage were significantly decreased.
2. The slight analgesic effect of Shintongchugeotang extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time.
3. The drug increased the auricular blood flow in rabbit.
4. The drug relaxed the artery contraction by pretreated norepinephrine in rat.
5. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen.
6. The drug inhibited the platelet aggregation in rat.
7. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable.
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